Schizophrenia Initially 10 or 15 mg once daily. Maintenance: 15 mg once daily. Bipolar mania Initially 15 mg once daily, may be increased to 30 mg once daily based on clinical response, adjusted at intervals not <24 hr.
Discontinue use if NMS, tardive dyskinesia or impulse-control problems occur. Hyperglycemia & DM. Orthostatic hypotension, known CV disease eg, history of MI or ischemic heart disease, heart failure or conduction abnormalities; history of seizure or conditions lowering seizure threshold eg, Alzheimer's dementia; body temp regulation; patients at risk for aspiration pneumonia; suicide. Pathological gambling, hypersexuality & impulse-control problems eg, personal or family history of obsessive-compulsive, impulse-control & bipolar disorders, impulsive personality, alcoholism, drug abuse or other addictive behaviours. Avoid overheat exposure & dehydration; alcohol. Concomitant use w/ prescription or over-the-counter drugs. May affect ability to drive & use machines. Not to be used during pregnancy & lactation. Paed <18 yr. Elderly ≥65 yr.
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